From Pamela Prindle Fierro,
Your Guide to Twins & Multiples.
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Pack only what you'll need while you're in transit, and things you'd need in case of an emergency. Pack light -- you'll have your hands full enough already!

Because restrictions on carry-on items change often, it's important to consult an official source or your airline before traveling. The TSA (Transportation Security Administration) maintains this page detailing permissible and prohibited items.

Make a list of the things you would normally use during the time frame of your flight:

diapers

bottles/formula (check TSA regulations)

drinks (check TSA regulations)

food

comfort items

medicines

Then plan for emergencies.

Extra outfits for each child (and a change of clothes for the parents too!)

Wet rag or wipes for cleaning up messes

Teething rings

Diaper changing pad and supplies

Snacks

Toys

Gallon-size zip top plastic bags for containing messes

Medicine -- always pack all prescriptions and medications in your carry on!

Make sure each parent has a "supply kit" in case you have to split up. One easy way to do that is to pack two smaller bags within a larger carryon. On the plane, you can each take a small bag to put under the seat, while the large bag goes overhead. Yet, everything is consolidated before and after the flight so that you're not juggling too many bags.

Next: What should we bring with us?