Most parents' biggest concern about flying with young multiples is keeping them comfortable and quiet during the trip. The most common factor that causes babies to cry in flight is ear pain. Changes in cabin pressure causes discomfort to tiny ears. Check with your pediatrician before you depart. Some may recommend giving young twins a common pain reducer like Tylenol or antihistamine like Benadryl to make them comfortable. Giving them something to drink -- nursing, a bottle, a sippy cup or juice box -- during takeoff and landing helps avoid uncomfortable ear pressure.
Hunger is another factor that causes distress. Try to conform to your twins' usual feeding schedule as much as possible. Pack light snacks that are appropriate for their age. Cheerios, pretzels, crackers and fruit roll ups don't make too much mess. If a meal is served during your flight, you can pre-order childrens' meals to ensure that the food is kid-friendly.
And of course, dirty diapers can be the cause of crying. Changing diapers in-flight can be tricky. Some larger planes have facilities in the lavatory. On smaller planes, it may be easier to do it in the seat, as long as you are courteous about other passengers. This is a good time to enlist the help of flight attendants, who may be able to suggest the best option. Many parents recommend putting toddlers in pull ups rather than diapers, to make changes easier.
If your twins are old enough, you'll need to arm yourself with entertainment ammunition. Choose your weapons carefully! Avoid things that are irretrievable, breakable, irreplaceable or contain multiple pieces. No matter what it is, pack two! Whatever one has, the other twin will want as well. Buy a few new toys just for the trip. Something new will hold their attention longer. Consider travel Magna Doodle or other non-marking art toys rather than crayons or markers to reduce mess.
Don't overdo it. Save some treats for the return flight, if necessary. In many cases, the excitement of a new experience will keep little ones entertained for a good portion of the flight.

